Just a few things I have noticed...

-When describing the clans, there doesn't seem to be nearly as much mention of sect. Under "organization" it usually restricts its description to how the clan organizes itself. For example, the Lasombra description never mentions any connections to the Sabbat.

-No mentions of antitribu. This goes along with the fact that this version seems to abandon the sects as large, umbrella organizations which the clans fall under.

-Bloodlines are merits. This suggests that, for example, to make a Noiad you would roll up...