Satchel has addressed most of your questions, but I'll add a bit more:
Regarding the number of Deviants one might find in a city, the usual "as many as your plot requires" still applies, but my sense is that they're more common than most major splats. Yes, the failure rate of a conspiracy trying to make new Remade is eye-popping, and even a careful and highly successful conspiracy that is capable of some degree of "mass production" still makes mistakes that kill or permanently damage their subjects (without the consolation of Variations). But many conspiracies...
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