I’d want it based on V:tM. It is the most popular WoD line and the vampires in it are more like vampires that people are familiar with. It also has the potential for a lot of interesting intrigue and politics.

I suppose I’d make the series basically like Game of Thrones. There would be a large cast of characters who are varying levels of shades of gray, often dark gray, with a few truly evil characters. There could be various factions scheming against each other, each with sympathetic characters.