To offer my personal route for the second generation, I decided I wanted the Lilith vs. Caine conflict and the Ravnos vs. Gangrel conflict to have more stuff going on to support them. So I ended up with having five members of the second generation. I kept Irad, Zillah, and Enoch around to have created 11 or the clans and have their own internal battles as the children of Caine within the city. However I wanted the wandering clans the Ravnos and Gangrel to have always been wanderers to support their behavior. So for the Gangrel, I went with that story about bloodbonding and the crone from the book...