In the games I've run and played in, I've seen some significant intimacy changes. I've never seen a defining intimacy go down, but the PC I played ended up with a minor tie to his familiar developing into a defining one. He certainly developed a couple of major intimacies, and a host of minor ones. In the game I run, I've definitely managed to develop intimacies up to the major level in PCs mostly through the work of NPCs to persuade them. In most cases they're ones that the character could have spent willpower on avoiding, but which the player thought would be an interesting turn for the character....