Personally I have always quite enjoyed the idea that everybody hates the Tremere and have made sure to include that exact sentiment in my games. Playing with this ingrained hatred and distrust both in game and OOC is a really useful tool to construct story-lines, plots and characters that in the 15 years I have been running games have contributed to the Tremere being one of my favourite clans.

As for their clan weakness, it can be as problematic as the ST wants it to be just like every other weakness... every single Tremere PC that has played in one of my games has begun with some...