I am a huge fan of "buffing" Fortitude. I've done something similar in my house rules -- allowing Fortitude to not only increase Soak, but also to simply cancel out non-aggravated damage 1:1. (I should note that my homebrew rules are such a departure and fundamental reorganization of the game mechanics, though, that this doesn't necessarily mean what it sounds like.) Still, there is a reason that the Ventrue are on top.

As for generation, I completely endorse Haquim's approach. (I assign my PCs sires and they live with whatever comes from that.) But I think that...