Also, if you read the final piece of fiction in Ascension, which effectively ends the story of Amanda, it's pretty clear that something is wrong with her. Senex's fix may not be holding. But that story takes place in the Judgment scenario, so the Nephandi are actually fighting alongside the Traditions, Technocracy, and Marauders against Voormas, whose plan for the universe is worse than Nephandic Descension.