While I'd like to see more Italy in CofD, Ancient Rome and Renaissance are the easiest choices... I'd take them, but I think there are other options. Just a few examples:

• VIII-396 B.C, Etruria vs early Rome [Vampire/Mage/Geist]: Second Chances already suggested it and I was like "YES". Ok, ok, I said no Ancient Rome... but Rome in this case is a footnote. Rome in this era would be at first "that annoying neighbor", then "that city we ruled for a while" and in the end "THE ENEMY". I don't know how much is said, if at all, about the Etruscans
...