Tremere - Noone likes the Tremere, they are tolerated in the Camarilla due to their monopoly of Thaumaturgy. They are not trusted. Every Tremere has a +1 difficulty on any social interaction with other clans when it comes to trusting them, and positive social effects. +2 for diff for Nosferatu, Gangrel and Assamite, +3 diff for Salubri and Tzimisce.
This is very similar to the "Clan flaw" of the camarilla Caitiffs

Tzimisce - Can't enter home uninvited. Trying to enter a home without an invitation requires a Willpower roll at diff 8. Each success allows the character...