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Tzimisce make most sense to me as a Nosferatu Bloodline with Protean both in theme as they're creepy flesh crafters and by Disaplins as Vigour is used as the make it do something extra for a devotion disaplin to push Protean onto another.

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I like to give players something when I'm running a campaign, in my current vampire game I gave them a group haven from their Sire but anything that the group think of as theirs is good. I suggest having a relatively infiuencal NPC who values Humanity and an understanding of proper technique (ie. skills) who can serve as a mentor/contact/quest giver for the party if they keep him happy (the way many video games make the good alignment path better in terms of party members and player homes). Also I allow players to take the Professional Training merit from CofD which helps make their go to skills...

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Shadow runners know not to make deals with dragons, the same should be true of vampires and Strix. Oh well I guess it's time to go swimming.
What pray tell would have happened if they had asked her to deal with LaCroix instead?

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I notice the lack of I
Sir Isaac Newton's Principia, he was into alchemy and the occult.
On the vampire writer side of things don't forget that academic disputes could be played out over published works. As an example a Mekhet might publish a paper on how Vitae requirements of clan Disaplins affects behaviour (and ethics) and end up in an ongoing dispute with a Ventrue.

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I don't know what abilities Vicissitude actually gives but I have some understanding of the theme.
For anything that involves inflicting change on another's flesh I would make a vigour devotion, for deceptive shape shifting I would make an Obfuscate devotion. Beyond that I don't know enough to helpfully contribute.