I tend to not let the whole "Oh look, The Old Gods are real!" impact my world by making sure that the governments and the churches actively suppress it. The governments do it because, if the general public knew that there were deities and they had divine powers, then why go to work? Just go to church and hope that your deity feeds you. The churches do it since they are not wanting it to get out that they could be wrong. These others are just the devil in disguise.

That is not to mention Fatebinding issues that can occur.

Now, I may alter my Scion world in 2e...