I think the Beads would fracture. Being the largest tribe it seems ideological splits would be possible and I think different heads of the Hydra would want to control the Garou.

So, they were always associated with the Beast of War and I think the Green Dragon stepping up would be a good replacement. I think a spirit of Famine or possibly even the spiritual imprint of Pentex would be a great choice for the Eater of Souls. The Defiler would be a bit harder. Possibly Bat? Given he is a fallen totem and corrupt but I'm sure there are better ones if I did some reading